SMC3

Across TCGA pan-cancer cohorts, SMC3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SMC3 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SMC3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SMC3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, HNSC, and OV are the cancer types where SMC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.872	0.413	.008	11	view →
HNSC	DFS	Quartile	IV	0.603	0.888	.017	5	view →
OV	DFS	Median	All	0.870	1.000	.037	4	view →
PDAC	OS	Median	II,III,IV	0.269	0.521	.005	4	view →
CCRCC	DFS	Median	IV	0.932	0.382	.031	4	view →
LUAD	DFS	Tertile	II,III,IV	0.780	0.906	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SMC3–LSCC (DFS)

Open the LSCC breakdown →