SMC3

Across TCGA patient cohorts, SMC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,084 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMC3-associated proteins across cancer lineages are MCMBP, SMC1A, and CWF19L1. Each is linked with SMC3 in more than 7 cancer types. Because this analysis shows association rather than direction, both SMC3-to-partner and partner-to-SMC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMC3 versus MCMBP in LUAD, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC3→partner) and Y-score (partner→SMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCMBP →	+0.386	+0.527	<.001	<.001	3	8
GBM	SMC1A →	+0.327	+0.409	<.001	<.001	3	8
OV	CWF19L1 →	+0.300	+0.411	<.001	<.001	3	8
GBM	TMPO →	+0.404	+0.444	<.001	<.001	3	7
GBM	RAD21 →	+0.328	+0.517	.001	<.001	3	7
OV	SMNDC1 →	+0.295	+0.463	.007	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,084 associations by consensus.

SMC3 vs MCMBP — LUAD

Explore this scatter interactively →