SMC3

Across TCGA patient cohorts, SMC3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMC3-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and JNK_pT183_Y185. Each is linked with SMC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMC3-to-partner and partner-to-SMC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SMC3-low versus SMC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC3→partner) and Y-score (partner→SMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.216	-1.906	.007	.015	3	2
UCEC	eIF4E →	+0.155	+2.820	.023	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.126	-1.415	.021	.043	3	2
UCEC	MEK1 →	+0.405	+3.807	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.582	+3.107	<.001	<.001	3	2
UCEC	SCD →	-0.077	-1.893	.030	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

EGFR_pY1068 by SMC3 expression — UCEC

Explore this box plot interactively →