SMC3

Across TCGA cell cohorts, SMC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,410 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SMC3-associated GO terms across cancer lineages are Spindle elongation, Regulation of chromosome condensation, and Nuclear chromosome segregation. Each is linked with SMC3 in more than 18 cancer types. Because this analysis shows association rather than direction, both SMC3-to-partner and partner-to-SMC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by SMC3-low versus SMC3-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC3→partner) and Y-score (partner→SMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Spindle elongation →	+0.231	+0.926	<.001	<.001	3	19
OVARY	Regulation of chromosome condensation →	+0.178	+1.053	<.001	<.001	3	19
BLOOD_Leukemia	Nuclear chromosome segregation →	+0.098	+0.956	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.216	+1.451	<.001	<.001	3	18
KIDNEY	Establishment of meiotic sister chromatid cohesion →	+0.240	+0.966	<.001	.001	3	18
LUNG_NSCLC_LUSC	Regulation of sister chromatid cohesion →	+0.132	+0.942	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,410 associations by consensus.

Spindle elongation by SMC3 expression — KIDNEY

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