SMC1A

Across TCGA pan-cancer cohorts, SMC1A mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SMC1A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SMC1A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SMC1A is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where SMC1A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMC1A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.357	<.001	10	view →
LSCC	Male	All	+0.292	<.001	8	view →
HNSC	Male	II,III,IV	+0.196	<.001	8	view →
LUAD	Male	All	+0.158	<.001	6	view →
CCRCC	Male	All	+0.141	<.001	6	view →
PDAC	All	IV	−0.307	.028	2	view →
OV	All	All	+0.256	.047	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

SMC1A–COAD

Open the COAD breakdown →