SMARCE1

Across TCGA pan-cancer cohorts, SMARCE1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMARCE1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMARCE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMARCE1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where SMARCE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.634	0.973	<.001	52	view →
LSCC	DFS	Median	All	0.972	0.905	.006	6	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	6	view →
UCEC	OS	Median	All	0.917	0.981	.040	2	view →
CCRCC	OS	Quartile	III,IV	0.887	0.583	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SMARCE1–HNSC (DFS)

Open the HNSC breakdown →