SMARCD2

Across TCGA patient cohorts, SMARCD2 mutation is significantly associated with the RNA expression of many other genes, with 1,475 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCD2-associated genes across cancer lineages are RNU6-929P, PCSK1N, and KCTD9. Each is linked with SMARCD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMARCD2-to-partner and partner-to-SMARCD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-929P grouped by SMARCD2-low versus SMARCD2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCD2→partner) and Y-score (partner→SMARCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU6-929P →	+0.514	+3.736	<.001	.008	3	3
UCEC	PCSK1N →	-1.476	-3.689	<.001	.001	3	2
UCEC	KCTD9 →	+0.685	+3.828	<.001	<.001	3	2
UCEC	MED31 →	+0.440	+2.928	<.001	<.001	3	2
UCEC	NCAPG →	+0.639	+2.595	.003	.005	3	2
UCEC	CYP27B1 →	+0.500	+3.013	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,475 associations by consensus.

RNU6-929P by SMARCD2 expression — STAD

Explore this box plot interactively →