SMARCD1

Across TCGA patient cohorts, SMARCD1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCD1-associated genes across cancer lineages are INPP4B, MEK1, and Notch1. Each is linked with SMARCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCD1-to-partner and partner-to-SMARCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SMARCD1-low versus SMARCD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCD1→partner) and Y-score (partner→SMARCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.251	-2.115	.038	.017	3	1
UCEC	MEK1 →	+0.337	+1.415	.013	.046	3	1
UCEC	Notch1 →	+0.150	+1.765	.004	.014	3	1
UCEC	p27_pT198 →	+0.087	+1.415	.030	.046	3	1
UCEC	p62 Lck ligand →	+0.466	+2.232	<.001	.005	3	1
UCEC	PCNA →	+0.240	+2.169	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

INPP4B by SMARCD1 expression — UCEC

Explore this box plot interactively →