SMARCC2

Across TCGA patient cohorts, SMARCC2 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCC2-associated genes across cancer lineages are c-Met_pY1235, ER-alpha_pS118, and STAT3_pY705. Each is linked with SMARCC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMARCC2-to-partner and partner-to-SMARCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by SMARCC2-low versus SMARCC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCC2→partner) and Y-score (partner→SMARCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.048	+1.299	.026	.013	3	3
BLCA	ER-alpha_pS118 →	+0.149	+2.472	.001	.010	3	2
UCEC	STAT3_pY705 →	-0.392	-2.048	<.001	<.001	3	2
BLCA	CD20 →	+0.125	+2.025	.001	.016	3	2
UCEC	MSH2 →	-0.173	-1.651	.010	.019	3	2
UCEC	Notch1 →	+0.143	+1.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

c-Met_pY1235 by SMARCC2 expression — UCEC

Explore this box plot interactively →