SMARCC1

Across TCGA cell cohorts, SMARCC1 protein abundance is significantly associated with the go_rna of many other GO terms, with 3,169 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMARCC1-associated GO terms across cancer lineages are Negative regulation of collagen metabolic process, Negative regulation of actin filament depolymerization, and Negative regulation of collagen biosynthetic process. Each is linked with SMARCC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SMARCC1-to-partner and partner-to-SMARCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of collagen metabolic process grouped by SMARCC1-low versus SMARCC1-high in OVARY.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCC1→partner) and Y-score (partner→SMARCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of collagen metabolic process →	-0.188	-1.001	<.001	.005	3	5
OVARY	Negative regulation of actin filament depolymerization →	-0.164	-0.961	<.001	.009	3	4
OVARY	Negative regulation of collagen biosynthetic process →	-0.179	-1.167	<.001	<.001	3	4
SKIN	Regulation of vesicle size →	-0.075	-0.838	.003	.004	3	3
LUNG_NSCLC_LUAD	Innate immune response activating cell surface receptor signaling pathway →	-0.068	-1.102	.001	.001	3	3
LUNG_NSCLC_LUAD	Regulation of granulocyte differentiation →	-0.118	-0.824	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,169 associations by consensus.

Negative regulation of collagen metabolic process by SMARCC1 expression — OVARY

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