SMARCC1

Across TCGA cell cohorts, SMARCC1 mutation is significantly associated with the RNA expression of many other genes, with 214 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMARCC1-associated genes across cancer lineages are AKAP4, TCP11X2, and HTR3D. Each is linked with SMARCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCC1-to-partner and partner-to-SMARCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKAP4 grouped by SMARCC1-low versus SMARCC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCC1→partner) and Y-score (partner→SMARCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AKAP4 →	+0.010	+3.544	.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	TCP11X2 →	+0.019	+4.736	<.001	.009	3	1
BLOOD_Lymphoma	HTR3D →	+0.015	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	RGS21 →	+1.001	+4.350	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRT84 →	+0.066	+3.760	<.001	.008	3	1
LUNG_NSCLC_LUAD	SLC6A19 →	+0.601	+3.977	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 214 associations by consensus.

AKAP4 by SMARCC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →