SMARCC1

Across TCGA cell cohorts, SMARCC1 mutation is significantly associated with the mutation status of many other genes, with 3,179 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMARCC1-associated genes across cancer lineages are TBR1, DCLRE1A, and OBSL1. Each is linked with SMARCC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SMARCC1-to-partner and partner-to-SMARCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBR1 grouped by SMARCC1-low versus SMARCC1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCC1→partner) and Y-score (partner→SMARCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TBR1 →	+6.044	+6.044	.001	.001	1	5
CNS	DCLRE1A →	+6.044	+6.044	.001	.001	1	4
UPPER_AERODIGESTIVE_TRACT	OBSL1 →	+4.954	+4.392	.008	.008	1	4
BLOOD_Lymphoma	TRPM3 →	+3.969	+3.969	.002	.002	1	4
LUNG_NSCLC_LUAD	ARFGEF3 →	+3.000	+3.662	.007	.007	1	4
LUNG_NSCLC_LUAD	EPHA7 →	+3.263	+3.851	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,179 associations by consensus.

TBR1 by SMARCC1 expression — CNS

Explore this box plot interactively →