SMARCB1

Across TCGA patient cohorts, SMARCB1 mutation is significantly associated with the RNA expression of many other genes, with 903 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCB1-associated genes across cancer lineages are OR4D10, DNAJA1P1, and RNU6-1180P. Each is linked with SMARCB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCB1-to-partner and partner-to-SMARCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4D10 grouped by SMARCB1-low versus SMARCB1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCB1→partner) and Y-score (partner→SMARCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR4D10 →	+0.098	+4.984	<.001	.003	3	2
CESC	DNAJA1P1 →	+0.033	+4.891	<.001	<.001	3	2
SKCM	RNU6-1180P →	+0.192	+4.039	<.001	.009	3	2
SKCM	MIR623 →	+0.541	+3.112	<.001	.004	3	2
UCEC	KIAA0513 →	+0.662	+3.364	<.001	.004	3	2
UCEC	KLF4 →	+0.848	+2.415	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 903 associations by consensus.

OR4D10 by SMARCB1 expression — CESC

Explore this box plot interactively →