SMARCB1

Across TCGA patient cohorts, SMARCB1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCB1-associated genes across cancer lineages are PCNA, PDK1_pS241, and E-Cadherin. Each is linked with SMARCB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCB1-to-partner and partner-to-SMARCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SMARCB1-low versus SMARCB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCB1→partner) and Y-score (partner→SMARCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.193	+3.000	.048	.036	3	1
UCEC	PDK1_pS241 →	+0.170	+3.026	.027	.018	3	1
UCEC	E-Cadherin →	-0.592	-2.700	.006	.006	3	1
UCEC	MEK1 →	+0.494	+2.700	.002	.006	1	1
UCEC	Cyclin-E1 →	+0.466	+2.000	.017	.032	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PCNA by SMARCB1 expression — UCEC

Explore this box plot interactively →