SMARCB1

Across TCGA cell cohorts, SMARCB1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SMARCB1-associated genes across cancer lineages are HMHB1, MS4A6E, and LRRC3B. Each is linked with SMARCB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCB1-to-partner and partner-to-SMARCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMHB1 grouped by SMARCB1-low versus SMARCB1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCB1→partner) and Y-score (partner→SMARCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HMHB1 →	+0.096	+5.087	<.001	.004	3	1
URINARY_TRACT	MS4A6E →	+0.043	+5.087	<.001	.004	3	1
URINARY_TRACT	LRRC3B →	+0.043	+5.087	<.001	.004	3	1
URINARY_TRACT	OR10Q1 →	+0.036	+5.087	<.001	.004	3	1
URINARY_TRACT	MTRNR2L6 →	+0.013	+5.087	<.001	.004	3	1
SOFT_TISSUE	MLNR →	+0.203	+2.977	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

HMHB1 by SMARCB1 expression — URINARY_TRACT

Explore this box plot interactively →