SMARCAL1

Across TCGA patient cohorts, SMARCAL1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCAL1-associated genes across cancer lineages are ATM, 14-3-3_beta, and EGFR_pY1068. Each is linked with SMARCAL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMARCAL1-to-partner and partner-to-SMARCAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SMARCAL1-low versus SMARCAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCAL1→partner) and Y-score (partner→SMARCAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.392	-1.861	.011	.049	3	3
UCEC	14-3-3_beta →	-0.085	-2.673	.012	.005	3	2
UCEC	EGFR_pY1068 →	-0.232	-1.514	.006	.015	3	2
UCEC	INPP4B →	-0.286	-1.794	.009	.004	3	2
UCEC	JNK_pT183_Y185 →	-0.189	-2.124	<.001	.001	3	2
UCEC	JNK2 →	+0.212	+1.901	.001	.028	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by SMARCAL1 expression — UCEC

Explore this box plot interactively →