SMARCAL1

Across TCGA cell cohorts, SMARCAL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,836 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMARCAL1-associated GO terms across cancer lineages are Positive regulation of lamellipodium assembly, Caveolin-mediated endocytosis, and Retrograde transport, endosome to Golgi. Each is linked with SMARCAL1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SMARCAL1-to-partner and partner-to-SMARCAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of lamellipodium assembly grouped by SMARCAL1-low versus SMARCAL1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCAL1→partner) and Y-score (partner→SMARCAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of lamellipodium assembly →	+0.108	+0.558	.001	.005	3	13
STOMACH	Caveolin-mediated endocytosis →	+0.184	+0.720	.002	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Retrograde transport, endosome to Golgi →	+0.059	+0.737	.003	<.001	3	12
BREAST	Mitotic centrosome separation →	+0.178	+0.635	<.001	.003	3	12
LUNG_NSCLC_LUSC	COP9 signalosome assembly →	+0.157	+0.522	.002	.002	3	11
SKIN	Endosomal transport →	+0.050	+0.553	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,836 associations by consensus.

Positive regulation of lamellipodium assembly by SMARCAL1 expression — STOMACH

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