SMARCAD1

Across TCGA patient cohorts, SMARCAD1 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCAD1-associated genes across cancer lineages are Akt_pT308, Cyclin-E2, and eIF4E. Each is linked with SMARCAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCAD1-to-partner and partner-to-SMARCAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by SMARCAD1-low versus SMARCAD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCAD1→partner) and Y-score (partner→SMARCAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Akt_pT308 →	+0.533	+3.008	.001	.019	3	2
COAD	Cyclin-E2 →	+0.269	+2.832	.025	.034	3	2
UCEC	eIF4E →	+0.151	+1.925	.015	.004	3	2
UCEC	FoxM1 →	+0.159	+1.058	.036	.037	3	2
UCEC	FOXO3a_pS318_S321 →	-0.089	-1.279	.014	.021	3	2
UCEC	PDCD4 →	-0.385	-1.241	.005	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Akt_pT308 by SMARCAD1 expression — COAD

Explore this box plot interactively →