SMARCA5

Across TCGA pan-cancer cohorts, SMARCA5 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SMARCA5 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher SMARCA5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SMARCA5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

SCLC, UCEC, and DLBC are the cancer types where SMARCA5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.082	0.708	<.001	36	view →
UCEC	DFS	Median	All	0.980	0.597	<.001	36	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
LUSC	DFS	Median	All	1.000	0.368	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SMARCA5–SCLC (OS)

Open the SCLC breakdown →