SMARCA2

Across TCGA cell cohorts, SMARCA2 mutation is significantly associated with the RNA expression of many other genes, with 1,071 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMARCA2-associated genes across cancer lineages are TBC1D28, NXF5, and ICOS. Each is linked with SMARCA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCA2-to-partner and partner-to-SMARCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D28 grouped by SMARCA2-low versus SMARCA2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCA2→partner) and Y-score (partner→SMARCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TBC1D28 →	+0.036	+4.050	<.001	.002	3	2
CNS	NXF5 →	+0.032	+4.087	<.001	.004	3	2
STOMACH	ICOS →	+0.121	+3.209	.006	.007	3	2
SKIN	OR6B3 →	+0.081	+4.437	<.001	.004	3	2
LARGE_INTESTINE	TMED8 →	+0.478	+2.265	.003	.001	3	2
LARGE_INTESTINE	ZMYND8 →	-0.633	-2.584	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,071 associations by consensus.

TBC1D28 by SMARCA2 expression — URINARY_TRACT

Explore this box plot interactively →