SMARCA1

Across TCGA pan-cancer cohorts, SMARCA1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMARCA1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SMARCA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SMARCA1 expression acts as an unfavorable survival marker.

CCRCC, PDAC, and HNSC are the cancer types where SMARCA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.582	0.978	<.001	81	view →
PDAC	OS	Tertile	All	0.379	0.677	<.001	57	view →
HNSC	OS	Quartile	All	0.747	0.971	.007	30	view →
UCEC	OS	Median	All	0.903	1.000	.007	14	view →
LSCC	DFS	Quartile	All	0.635	0.876	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SMARCA1–CCRCC (OS)

Open the CCRCC breakdown →