SMARCA1

Across TCGA patient cohorts, SMARCA1 mutation is significantly associated with the RNA expression of many other genes, with 3,823 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCA1-associated genes across cancer lineages are CCNB2, CDT1, and UFD1. Each is linked with SMARCA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMARCA1-to-partner and partner-to-SMARCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNB2 grouped by SMARCA1-low versus SMARCA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCA1→partner) and Y-score (partner→SMARCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNB2 →	+0.555	+1.415	<.001	<.001	3	3
UCEC	CDT1 →	+0.801	+2.032	<.001	<.001	3	3
UCEC	UFD1 →	+0.398	+1.603	<.001	<.001	3	3
UCEC	TIPIN →	+0.529	+2.191	<.001	<.001	3	3
UCEC	ORC1 →	+0.556	+1.798	<.001	.001	3	3
CESC	CCL27 →	+0.065	+4.812	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,823 associations by consensus.

CCNB2 by SMARCA1 expression — UCEC

Explore this box plot interactively →