SMARCA1

Across TCGA cell cohorts, SMARCA1 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMARCA1-associated genes across cancer lineages are BANF2, PLA2G3, and EIF3D. Each is linked with SMARCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMARCA1-to-partner and partner-to-SMARCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BANF2 grouped by SMARCA1-low versus SMARCA1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCA1→partner) and Y-score (partner→SMARCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BANF2 →	+0.096	+5.643	<.001	.002	3	1
LARGE_INTESTINE	PLA2G3 →	+1.233	+3.385	<.001	.004	3	1
LARGE_INTESTINE	EIF3D →	+0.432	+3.212	.006	.006	3	1
LARGE_INTESTINE	CTH →	+1.219	+3.212	.002	.006	3	1
LARGE_INTESTINE	SYF2 →	+0.465	+3.212	.008	.006	3	1
LARGE_INTESTINE	PSMG2 →	+0.531	+3.299	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

BANF2 by SMARCA1 expression — BLOOD_Lymphoma

Explore this box plot interactively →