SMAP2

Across TCGA pan-cancer cohorts, SMAP2 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SMAP2 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SMAP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMAP2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

COAD, LUAD, and HNSC are the cancer types where SMAP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.787	1.000	.017	54	view →
LUAD	DFS	Quartile	All	0.828	0.298	<.001	32	view →
HNSC	DFS	Tertile	III,IV	0.660	0.876	.012	12	view →
LSCC	OS	Tertile	III,IV	0.970	0.672	.024	8	view →
PDAC	DFS	Quartile	All	0.883	0.635	.026	7	view →
UCEC	OS	Quartile	III,IV	1.000	0.374	.042	4	view →
CCRCC	OS	Median	II,III,IV	1.000	0.435	.015	2	view →
GBM	OS	Tertile	All	0.349	0.549	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SMAP2–COAD (DFS)

Open the COAD breakdown →