SMAP2

Across TCGA patient cohorts, SMAP2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAP2-associated genes across cancer lineages are PDCD4, TFRC, and ATM. Each is linked with SMAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAP2-to-partner and partner-to-SMAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SMAP2-low versus SMAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAP2→partner) and Y-score (partner→SMAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.667	-2.700	<.001	.005	3	2
UCEC	TFRC →	+0.563	+2.321	.006	.034	3	2
UCEC	ATM →	-0.597	-2.502	<.001	.002	3	2
UCEC	EGFR →	-0.127	-2.973	.043	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.152	-1.571	.021	.036	3	1
UCEC	JNK2 →	+0.219	+2.000	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PDCD4 by SMAP2 expression — UCEC

Explore this box plot interactively →