SMAP2

Across TCGA cell cohorts, SMAP2 protein abundance is significantly associated with the go_rna of many other GO terms, with 3,395 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMAP2-associated GO terms across cancer lineages are Maintenance of blood-brain barrier, Regulation of oocyte maturation, and Nucleosome assembly. Each is linked with SMAP2 in more than 7 cancer types. Because this analysis shows association rather than direction, both SMAP2-to-partner and partner-to-SMAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of blood-brain barrier grouped by SMAP2-low versus SMAP2-high in OVARY.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAP2→partner) and Y-score (partner→SMAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Maintenance of blood-brain barrier →	-0.237	-1.445	<.001	.004	2	8
BLOOD_Myeloma	Regulation of oocyte maturation →	-0.210	-1.044	.003	.004	2	5
BLOOD_Myeloma	Nucleosome assembly →	+0.082	+0.953	<.001	.003	3	4
BLOOD_Leukemia	Salivary gland morphogenesis →	-0.220	-1.058	<.001	.004	3	4
BONE	Positive regulation of bone resorption →	-0.159	-1.607	.005	.002	2	5
LUNG_NSCLC_LUSC	Negative regulation of actin filament bundle assembly →	-0.123	-2.359	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,395 associations by consensus.

Maintenance of blood-brain barrier by SMAP2 expression — OVARY

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