SMAP1

Across TCGA pan-cancer cohorts, SMAP1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SMAP1 data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SMAP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SMAP1 expression acts as an unfavorable survival marker.

UCS, PRAD, and HNSC are the cancer types where SMAP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	All	0.104	0.688	<.001	36	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
HNSC	OS	Median	II,III,IV	0.222	0.710	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SMAP1–UCS (OS)

Open the UCS breakdown →