SMAP1

Across TCGA pan-cancer cohorts, SMAP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMAP1 data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SMAP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SMAP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

LSCC, COAD, and UCEC are the cancer types where SMAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.953	0.720	.005	24	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.909	.038	12	view →
UCEC	DFS	Quartile	All	0.958	0.674	.005	10	view →
HNSC	DFS	Quartile	All	1.000	0.867	.015	7	view →
PDAC	DFS	Tertile	II,III,IV	0.357	0.583	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SMAP1–LSCC (OS)

Open the LSCC breakdown →