SMAP1

Across TCGA patient cohorts, SMAP1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAP1-associated genes across cancer lineages are GATA6, Heregulin, and JNK_pT183_Y185. Each is linked with SMAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAP1-to-partner and partner-to-SMAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by SMAP1-low versus SMAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAP1→partner) and Y-score (partner→SMAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.126	-3.169	.043	.019	3	1
UCEC	Heregulin →	-0.129	-2.700	.006	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.129	-1.664	.045	.023	3	1
UCEC	JNK2 →	+0.276	+2.916	<.001	<.001	3	1
UCEC	Ku80 →	+0.260	+3.598	.004	.001	3	1
UCEC	NDRG1_pT346 →	-0.388	-2.115	.039	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GATA6 by SMAP1 expression — UCEC

Explore this box plot interactively →