SMAD9

Across TCGA patient cohorts, SMAD9 mutation is significantly associated with the RNA expression of many other genes, with 3,068 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD9-associated genes across cancer lineages are LINC02663, LINC02361, and C16orf95. Each is linked with SMAD9 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMAD9-to-partner and partner-to-SMAD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02663 grouped by SMAD9-low versus SMAD9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD9→partner) and Y-score (partner→SMAD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC02663 →	+0.218	+3.051	<.001	.003	3	3
COAD	LINC02361 →	+0.586	+3.223	.007	.009	3	3
UCEC	C16orf95 →	+0.262	+2.415	.005	.003	3	3
UCEC	MNAT1 →	+0.547	+3.475	.001	.002	3	3
UCEC	R3HCC1 →	+0.440	+2.592	.005	.006	3	2
UCEC	EFTUD2 →	+0.489	+3.716	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,068 associations by consensus.

LINC02663 by SMAD9 expression — COAD

Explore this box plot interactively →