SMAD9

Across TCGA patient cohorts, SMAD9 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD9-associated genes across cancer lineages are C-Raf, JNK_pT183_Y185, and EGFR_pY1068. Each is linked with SMAD9 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMAD9-to-partner and partner-to-SMAD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SMAD9-low versus SMAD9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD9→partner) and Y-score (partner→SMAD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.177	+2.815	.027	.036	3	3
UCEC	JNK_pT183_Y185 →	-0.154	-2.102	.036	.019	3	2
UCEC	EGFR_pY1068 →	-0.310	-3.459	.004	.005	3	2
UCEC	PCNA →	+0.268	+2.584	.004	.010	3	2
UCEC	Annexin-1 →	+0.623	+2.341	.006	.019	3	2
STAD	Caveolin-1 →	-0.947	-3.321	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

C-Raf by SMAD9 expression — COAD

Explore this box plot interactively →