SMAD9

Across TCGA cell cohorts, SMAD9 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,116 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SMAD9-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Microtubule-based transport, and Establishment of mitotic spindle localization. Each is linked with SMAD9 in more than 12 cancer types. Because this analysis shows association rather than direction, both SMAD9-to-partner and partner-to-SMAD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by SMAD9-low versus SMAD9-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD9→partner) and Y-score (partner→SMAD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of nucleotide-excision repair →	+0.133	+1.348	.003	.004	3	13
OESOPHAGUS	Microtubule-based transport →	+0.058	+1.000	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Establishment of mitotic spindle localization →	+0.101	+1.195	.001	<.001	2	13
BREAST	Microtubule cytoskeleton organization involved in mitosis →	+0.091	+0.730	<.001	.002	3	12
OESOPHAGUS	Regulation of microtubule-based process →	+0.069	+1.017	.002	.002	3	12
STOMACH	Epigenetic regulation of gene expression →	+0.097	+1.816	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,116 associations by consensus.

Regulation of nucleotide-excision repair by SMAD9 expression — STOMACH

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