SMAD6

Across TCGA patient cohorts, SMAD6 mutation is significantly associated with the RNA expression of many other genes, with 755 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD6-associated genes across cancer lineages are RNA5SP412, RNA5SP415, and EXOSC3P1. Each is linked with SMAD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMAD6-to-partner and partner-to-SMAD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by SMAD6-low versus SMAD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD6→partner) and Y-score (partner→SMAD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.475	+2.382	.006	.003	3	3
UCEC	RNA5SP415 →	+0.419	+2.488	.007	.004	3	3
SKCM	EXOSC3P1 →	+0.595	+3.208	<.001	.009	3	2
BLCA	C1QBPP1 →	+0.137	+6.018	<.001	.002	3	2
BLCA	MTCYBP45 →	+0.144	+5.038	<.001	.009	3	2
UCEC	RNA5SP414 →	+0.505	+2.255	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 755 associations by consensus.

RNA5SP412 by SMAD6 expression — UCEC

Explore this box plot interactively →