SMAD6

Across TCGA cell cohorts, SMAD6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,086 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SMAD6-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Nucleoside triphosphate biosynthetic process, and U2-type prespliceosome assembly. Each is linked with SMAD6 in more than 12 cancer types. Because this analysis shows association rather than direction, both SMAD6-to-partner and partner-to-SMAD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by SMAD6-low versus SMAD6-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD6→partner) and Y-score (partner→SMAD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of calcium ion export across plasma membrane →	+0.059	+1.488	<.001	<.001	3	13
OVARY	Nucleoside triphosphate biosynthetic process →	+0.105	+2.220	<.001	<.001	3	11
BREAST	U2-type prespliceosome assembly →	+0.115	+1.980	<.001	<.001	3	11
SOFT_TISSUE	Actin polymerization-dependent cell motility →	+0.157	+2.028	<.001	<.001	3	11
BREAST	Mitral valve development →	+0.096	+1.302	<.001	<.001	3	10
BREAST	Negative regulation of toll-like receptor signaling pathway →	+0.115	+2.338	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,086 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by SMAD6 expression — SOFT_TISSUE

Explore this box plot interactively →