SMAD5

Across TCGA pan-cancer cohorts, SMAD5 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SMAD5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMAD5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SMAD5 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and CCRCC are the cancer types where SMAD5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMAD5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−0.271	<.001	8	view →
LSCC	Male	All	−0.229	<.001	8	view →
CCRCC	Male	II,III,IV	+0.150	.002	5	view →
LUAD	Male	All	−0.140	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SMAD5–HNSC

Open the HNSC breakdown →