SMAD5-AS1

Across TCGA pan-cancer cohorts, SMAD5-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SMAD5-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SMAD5-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SMAD5-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and MESO show a favorable association.

LUSC, KICH, and LGG are the cancer types where SMAD5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	All	0.748	0.570	<.001	56	view →
KICH	DFS	Tertile	All	0.749	1.000	.007	50	view →
LGG	OS	Median	All	0.333	0.520	<.001	49	view →
MESO	OS	Median	All	0.489	0.287	.001	47	view →
BLCA	OS	Quartile	II,III,IV	0.641	0.771	.006	42	view →
HNSC	OS	Quartile	III,IV	0.541	0.244	.002	41	view →
UCEC	OS	Tertile	III,IV	0.732	0.871	.012	36	view →
UCS	DFS	Median	All	0.564	0.286	.007	34	view →
CESC	DFS	Quartile	All	0.857	0.629	<.001	28	view →
ACC	DFS	Tertile	All	0.217	0.725	.011	24	view →
PAAD	DFS	Quartile	All	0.464	0.266	.020	19	view →
ESCA	OS	Tertile	All	1.000	0.451	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SMAD5-AS1–LUSC (OS)

Open the LUSC breakdown →