SMAD3

Across TCGA patient cohorts, SMAD3 protein abundance is significantly associated with the RNA expression of many other genes, with 8,159 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMAD3-associated genes across cancer lineages are INTS14, HACD3, and SNX33. Each is linked with SMAD3 in more than 6 cancer types. Because this analysis shows association rather than direction, both SMAD3-to-partner and partner-to-SMAD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMAD3 versus INTS14 in HNSC, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD3→partner) and Y-score (partner→SMAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	INTS14 →	+0.572	+0.323	<.001	<.001	3	7
BRCA	HACD3 →	+0.688	+0.434	<.001	.001	3	7
HNSC	SNX33 →	+0.582	+0.278	.003	.009	3	6
HNSC	RAB11A →	+0.687	+0.340	.007	<.001	3	5
LSCC	ULK3 →	+0.473	+0.271	.003	.006	3	5
LUAD	ARIH1 →	+0.474	+0.469	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,159 associations by consensus.

SMAD3 vs INTS14 — HNSC

Explore this scatter interactively →