SMAD3

Across TCGA patient cohorts, SMAD3 mutation is significantly associated with the RNA expression of many other genes, with 1,286 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD3-associated genes across cancer lineages are RNA5SP84, SPTLC1P3, and MIR206. Each is linked with SMAD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMAD3-to-partner and partner-to-SMAD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP84 grouped by SMAD3-low versus SMAD3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD3→partner) and Y-score (partner→SMAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP84 →	+0.155	+4.722	<.001	.003	3	3
LIHC	SPTLC1P3 →	+0.157	+5.447	<.001	.005	3	3
COAD	MIR206 →	+0.177	+4.834	<.001	.001	3	3
UCEC	KRT18P9 →	+0.119	+1.603	.007	.005	3	3
UCEC	CINP →	+0.274	+1.705	<.001	.003	3	3
LIHC	MIR7976 →	+0.482	+5.268	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,286 associations by consensus.

RNA5SP84 by SMAD3 expression — BLCA

Explore this box plot interactively →