SMAD3

Across TCGA patient cohorts, SMAD3 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD3-associated genes across cancer lineages are FASN, GAPDH, and ASNS. Each is linked with SMAD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMAD3-to-partner and partner-to-SMAD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by SMAD3-low versus SMAD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD3→partner) and Y-score (partner→SMAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.405	+1.415	.006	.046	3	3
COAD	GAPDH →	+0.524	+3.334	.008	.005	3	3
UCEC	ASNS →	+0.326	+2.321	.016	.033	3	3
COAD	Rictor_pT1135 →	-0.107	-2.089	.044	.018	3	2
UCEC	FOXO3a_pS318_S321 →	-0.148	-3.077	.001	<.001	3	2
UCEC	Notch1 →	+0.124	+1.710	.018	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

FASN by SMAD3 expression — UCEC

Explore this box plot interactively →