SMAD3

Across TCGA cell cohorts, SMAD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,535 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SMAD3-associated GO terms across cancer lineages are Regulation of cell-matrix adhesion, Caveola assembly, and Regulation of cell-substrate junction organization. Each is linked with SMAD3 in more than 15 cancer types. Because this analysis shows association rather than direction, both SMAD3-to-partner and partner-to-SMAD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-matrix adhesion grouped by SMAD3-low versus SMAD3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD3→partner) and Y-score (partner→SMAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-matrix adhesion →	+0.135	+1.109	<.001	<.001	3	16
LARGE_INTESTINE	Caveola assembly →	+0.250	+1.402	<.001	<.001	3	16
BONE	Regulation of cell-substrate junction organization →	+0.122	+1.113	<.001	<.001	3	16
BONE	Positive regulation of cell-substrate junction organization →	+0.145	+1.097	<.001	<.001	3	16
SKIN	Regulation of transforming growth factor beta3 production →	+0.232	+1.294	.001	<.001	3	16
BREAST	Transdifferentiation →	+0.354	+1.259	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,535 associations by consensus.

Regulation of cell-matrix adhesion by SMAD3 expression — BONE

Explore this box plot interactively →