SMAD3

Across TCGA cell cohorts, SMAD3 protein abundance is significantly associated with the RNA expression of many other genes, with 2,881 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible SMAD3-associated genes across cancer lineages are PRMT9, TTC19, and SLC35B4. Each is linked with SMAD3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SMAD3-to-partner and partner-to-SMAD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMAD3 versus PRMT9 in CNS, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD3→partner) and Y-score (partner→SMAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRMT9 →	+0.405	+0.573	.002	.004	3	5
OESOPHAGUS	TTC19 →	+0.898	+0.630	.001	.002	3	4
URINARY_TRACT	SLC35B4 →	+1.160	+1.197	.003	.002	3	4
URINARY_TRACT	SUCLA2 →	+0.866	+0.926	<.001	.002	3	4
LARGE_INTESTINE	DFFA →	+1.013	+1.040	<.001	<.001	3	4
OVARY	KLK8 →	-3.881	-1.037	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,881 associations by consensus.

SMAD3 vs PRMT9 — CNS

Explore this scatter interactively →