SMAD3

Across TCGA cell cohorts, SMAD3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMAD3-associated genes across cancer lineages are SCGB1D4, GH1, and C9orf92. Each is linked with SMAD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAD3-to-partner and partner-to-SMAD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1D4 grouped by SMAD3-low versus SMAD3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD3→partner) and Y-score (partner→SMAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SCGB1D4 →	+0.130	+5.169	.004	.005	3	1
BREAST	GH1 →	+0.062	+5.169	<.001	.005	3	1
BLOOD_Leukemia	C9orf92 →	+0.147	+5.539	<.001	.003	3	1
LARGE_INTESTINE	NAA11 →	+0.372	+3.706	.001	.002	3	1
LARGE_INTESTINE	MMP26 →	+0.033	+3.217	<.001	.006	3	1
LARGE_INTESTINE	ELOA3DP →	+0.018	+3.103	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SCGB1D4 by SMAD3 expression — BREAST

Explore this box plot interactively →