SMAD2

Across TCGA patient cohorts, SMAD2 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,933 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMAD2-associated proteins across cancer lineages are SMAD4, RPRD1A, and TXNL1. Each is linked with SMAD2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SMAD2-to-partner and partner-to-SMAD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMAD2 versus SMAD4 in PDAC, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD2→partner) and Y-score (partner→SMAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SMAD4 →	+0.349	+0.504	<.001	<.001	3	9
LSCC	RPRD1A →	+0.372	+0.544	<.001	<.001	3	8
LSCC	TXNL1 →	+0.371	+0.709	<.001	<.001	3	6
COAD	KDSR →	+0.378	+0.664	<.001	<.001	3	6
OV	NARS1 →	+0.371	+0.460	<.001	<.001	3	6
LSCC	CTDP1 →	+0.240	+0.613	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,933 associations by consensus.

SMAD2 vs SMAD4 — PDAC

Explore this scatter interactively →