SMAD2

Across TCGA patient cohorts, SMAD2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD2-associated genes across cancer lineages are ACVRL1, 4E-BP1, and mTOR_pS2448. Each is linked with SMAD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMAD2-to-partner and partner-to-SMAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by SMAD2-low versus SMAD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD2→partner) and Y-score (partner→SMAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.107	-1.565	.017	.017	3	3
UCEC	4E-BP1 →	+0.305	+2.936	<.001	<.001	3	3
UCEC	mTOR_pS2448 →	-0.146	-2.482	.002	.001	3	2
UCEC	Annexin-1 →	+0.485	+2.107	.005	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.497	+1.505	.011	.034	3	2
COAD	p53 →	-0.291	-2.450	.038	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ACVRL1 by SMAD2 expression — UCEC

Explore this box plot interactively →