SMAD1

Across TCGA patient cohorts, SMAD1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,574 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SMAD1-associated proteins across cancer lineages are ARFGEF2, CNN3, and DPYSL3. Each is linked with SMAD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SMAD1-to-partner and partner-to-SMAD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMAD1 versus ARFGEF2 in COAD, with a Pearson correlation of -0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD1→partner) and Y-score (partner→SMAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ARFGEF2 →	-0.307	-0.395	<.001	.001	3	5
PDAC	CNN3 →	+0.611	+0.310	<.001	<.001	3	4
CCRCC	DPYSL3 →	+0.639	+0.586	<.001	<.001	3	4
UCEC	MMP2 →	+0.526	+0.419	<.001	<.001	3	4
GBM	HTATIP2 →	-0.771	-0.446	<.001	<.001	3	4
CCRCC	TAGLN →	+0.805	+0.447	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,574 associations by consensus.

SMAD1 vs ARFGEF2 — COAD

Explore this scatter interactively →