SMAD1

Across TCGA patient cohorts, SMAD1 mutation is significantly associated with the RNA expression of many other genes, with 498 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD1-associated genes across cancer lineages are RNA5SP325, NDUFA3P3, and UBL5P3. Each is linked with SMAD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMAD1-to-partner and partner-to-SMAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP325 grouped by SMAD1-low versus SMAD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD1→partner) and Y-score (partner→SMAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP325 →	+0.560	+2.103	.005	.006	3	3
UCEC	NDUFA3P3 →	+0.156	+2.418	.003	.005	3	2
UCEC	UBL5P3 →	+0.140	+2.674	.004	.006	3	2
SKCM	HMGN1P33 →	+0.053	+3.186	.003	.009	3	2
UCEC	VCY1B →	+0.026	+4.360	<.001	.004	3	2
SKCM	RN7SL453P →	+0.054	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 498 associations by consensus.

RNA5SP325 by SMAD1 expression — UCEC

Explore this box plot interactively →