SMAD1

Across TCGA patient cohorts, SMAD1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD1-associated genes across cancer lineages are eIF4E, MEK1, and MSH2. Each is linked with SMAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAD1-to-partner and partner-to-SMAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SMAD1-low versus SMAD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD1→partner) and Y-score (partner→SMAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.283	+3.459	.007	.005	3	1
UCEC	MEK1 →	+0.431	+2.321	.018	.035	3	1
UCEC	MSH2 →	-0.411	-2.321	<.001	.035	3	1
UCEC	PEA-15_pS116 →	+0.538	+3.459	.002	.005	3	1
UCEC	STAT3_pY705 →	-0.478	-3.159	<.001	.019	3	1
UCEC	ATM →	-0.653	-2.321	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

eIF4E by SMAD1 expression — UCEC

Explore this box plot interactively →