SMAD1

Across TCGA cell cohorts, SMAD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,931 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMAD1-associated GO terms across cancer lineages are Anti-Mullerian hormone receptor signaling pathway, Negative regulation of chromosome condensation, and Regulation of G0 to G1 transition. Each is linked with SMAD1 in more than 15 cancer types. Because this analysis shows association rather than direction, both SMAD1-to-partner and partner-to-SMAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Anti-Mullerian hormone receptor signaling pathway grouped by SMAD1-low versus SMAD1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD1→partner) and Y-score (partner→SMAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Anti-Mullerian hormone receptor signaling pathway →	+0.353	+1.194	<.001	.001	3	16
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.174	+1.316	<.001	.002	3	15
OVARY	Regulation of G0 to G1 transition →	+0.091	+0.802	.002	.008	3	14
STOMACH	Regulatory ncRNA processing →	+0.105	+0.962	.001	.004	3	13
STOMACH	Heterochromatin formation →	+0.064	+0.934	<.001	<.001	3	13
STOMACH	miRNA processing →	+0.101	+0.937	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,931 associations by consensus.

Anti-Mullerian hormone receptor signaling pathway by SMAD1 expression — BLOOD_Leukemia

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