SMAD1

Across TCGA cell cohorts, SMAD1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,367 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMAD1-associated genes across cancer lineages are CBX2, CHD4, and FBRSL1. Each is linked with SMAD1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SMAD1-to-partner and partner-to-SMAD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMAD1 versus CBX2 in LUNG_SCLC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD1→partner) and Y-score (partner→SMAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CBX2 →	+1.855	+0.688	.004	<.001	3	9
LIVER	CHD4 →	+0.899	+0.523	.007	.005	2	9
PANCREAS	FBRSL1 →	+1.242	+0.536	<.001	.004	2	9
BLOOD_Leukemia	FAM117B →	+0.875	+0.455	<.001	<.001	3	8
BLOOD_Lymphoma	HCFC1 →	+0.810	+0.269	.004	.001	3	8
LUNG_NSCLC_LUSC	MEX3A →	+2.840	+1.053	.003	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,367 associations by consensus.

SMAD1 vs CBX2 — LUNG_SCLC

Explore this scatter interactively →