SMAD1

Across TCGA cell cohorts, SMAD1 protein abundance is significantly associated with the go_rna of many other GO terms, with 2,792 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMAD1-associated GO terms across cancer lineages are DNA-templated transcription termination, Positive regulation of DNA recombination, and Regulation of DNA repair. Each is linked with SMAD1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SMAD1-to-partner and partner-to-SMAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription termination grouped by SMAD1-low versus SMAD1-high in KIDNEY.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD1→partner) and Y-score (partner→SMAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DNA-templated transcription termination →	+0.076	+0.789	.003	<.001	3	9
BLOOD_Lymphoma	Positive regulation of DNA recombination →	+0.059	+0.307	.003	.001	3	8
LUNG_SCLC	Regulation of DNA repair →	+0.062	+0.559	<.001	<.001	3	8
BLOOD_Leukemia	Host-mediated perturbation of viral transcription →	+0.090	+0.306	<.001	.001	3	8
BLOOD_Lymphoma	Regulation of double-strand break repair via homologous recombination →	+0.072	+0.308	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Positive regulation of DNA metabolic process →	+0.059	+0.967	.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,792 associations by consensus.

DNA-templated transcription termination by SMAD1 expression — KIDNEY

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